A daily oral that supports glucose balance, mitochondrial efficiency, and metabolic flexibility — one of the most-studied molecules in modern medicine.
Metformin is an oral biguanide that's been used clinically for more than sixty years and studied across millions of patient-years. It primarily lowers hepatic glucose output, improves insulin sensitivity, and influences cellular energy regulation through pathways like AMPK — the same pathway activated by exercise and caloric restriction.
Beyond its primary use in glucose management, it's increasingly part of clinician-guided longevity protocols because of its effects on mitochondrial efficiency, inflammation, and metabolic flexibility. None of those effects are dramatic week to week — metformin is a slow, durable lever, not a fast switch.
Your clinician begins at a low dose (typically 500 mg with the largest meal) and titrates upward as tolerated. Extended-release formulations dramatically reduce gastrointestinal side effects compared to immediate-release, and that's what we use by default unless there's a specific reason not to.
Metformin pairs well with GLP-1 protocols, lifestyle anchors, and other longevity tools. It is not a weight-loss drug, but improved insulin sensitivity often supports metabolic outcomes downstream.
Every member's curve is a little different. The shape below is the typical clinician-guided arc.
You begin at 500 mg with the largest meal of the day. The gut takes about a week to acclimate.
Your clinician reviews tolerance and may increase to twice-daily dosing. Most GI symptoms resolve at this stage.
First formal check-in: labs (A1c, fasting insulin), tolerance, and any other markers your clinician is tracking.
Ongoing dosing is steady-state. Some members run continuously; others cycle. Your clinician will guide the rhythm.
Metformin isn't for everyone, and we don't pretend otherwise. Your clinician will confirm fit during your eligibility review.
Loose stools, nausea, or stomach discomfort are most common in the first week or two. Extended-release formulation, slow titration, and dosing with food usually resolve it.
A faint metallic note in the mouth is reported by some members and tends to fade after the first few weeks.
Long-term metformin can modestly reduce vitamin B12 absorption. Your clinician monitors levels and supplements when warranted.
Extremely rare and tied to specific underlying conditions. Eligibility screening rules out the relevant risk factors before prescribing.
Billed monthly. Pause or cancel from your dashboard in one click. Final price is set after clinician review and may vary based on dose and protocol.
Take the twelve-minute eligibility review. A licensed clinician will read your intake, recommend a protocol — or tell you honestly that we're not the right fit. Either way, you'll know within a day.