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Metabolic Health · GLP-1

Semaglutide

A once-weekly GLP-1 protocol designed around the version of you that's been waiting to show up — calmer appetite, steadier energy, lasting change.

From $179 / month
Lab-verified 503A / 503B accredited Clinician-reviewed
A clean editorial product photograph of a single-use semaglutide vial in soft natural light
Form
Subcutaneous injection
Cadence
Once weekly
Onset
First effects in 4–6 weeks
Pharmacy
503A / 503B accredited
What it is

A weekly nudge to a calmer relationship with food.

Semaglutide is a GLP-1 receptor agonist — a synthetic analog of a hormone your gut already makes after meals. Naturally, GLP-1 tells your brain you've had enough, slows how quickly your stomach empties, and helps your pancreas modulate insulin release. Most people produce it in short, fragile pulses that fade within minutes.

The molecule we use is engineered to last. A single weekly dose maintains a steady level of GLP-1 activity for seven full days, which is why members tend to describe the experience not as appetite suppression but as appetite quieting — the chatter softens, food becomes a choice again, and the body's sense of fullness arrives sooner and lasts longer.

Your clinician begins at the lowest effective dose and titrates upward over several weeks. The goal is the gentlest curve that still produces meaningful change, not the fastest one — slow titration is how we keep nausea, fatigue, and GI symptoms manageable and rare.

Compounded semaglutide is dispensed only by accredited 503A or 503B U.S. pharmacies under your clinician's order. Every batch is tested for potency, sterility, pH, and endotoxins before it ever ships to a member.

Week by week

What to expect, in real time.

Every member's curve is a little different. The shape below is the typical clinician-guided arc for semaglutide.

1

Week 1 · Starting dose

You begin at the lowest effective dose to let your gut acclimate. Many members notice early fullness within the first week.

2

Week 4 · Titration

Your clinician reviews how you feel and increases your dose if appropriate. Cravings typically quiet and meals shrink naturally.

3

Week 12 · Re-evaluation

First formal check-in: weight, side-effect profile, labs. Dose is held, advanced, or paused based on response.

4

Week 24+ · Maintenance

Most members find a sustainable maintenance dose. Some taper. Either way, your clinician guides the off-ramp as carefully as the on-ramp.

Who it's appropriate for

Honest eligibility — before you ever pay.

Semaglutide isn't for everyone, and we don't pretend otherwise. Your clinician will confirm fit during your eligibility review.

A good fit for

  • Adults with a BMI in a clinically eligible range or related metabolic markers.
  • People who have struggled with sustainable weight loss through diet alone.
  • Members ready for a longer-arc protocol — not a 30-day fix.
  • Anyone comfortable with a once-weekly subcutaneous injection.

Not appropriate for

  • People with type 1 diabetes or a history of diabetic ketoacidosis.
  • Personal or family history of medullary thyroid carcinoma or MEN-2.
  • People who are pregnant, breastfeeding, or actively trying to conceive.
  • History of pancreatitis or severe gastrointestinal motility disorders.
Common effects · what we do about them

What can happen — and how your clinician helps.

Common

Nausea

Most often mild and tied to titration. We slow the dose curve, encourage smaller meals, and prescribe an as-needed antiemetic when warranted.

Common

Fatigue

Lower calorie intake plus shifting metabolism can drag energy in weeks 2–4. Hydration, electrolytes, and protein targets usually resolve it.

Common

Constipation

Slower gastric emptying changes transit time. Daily fiber, magnesium glycinate, and water targets are part of the protocol.

Occasional

Injection-site reaction

Mild redness or itch at the site is uncommon and self-resolving. Rotating sites and warming the dose to room temperature both help.

Pricing transparency

One flat price. No surprises.

Membership
$179/mo

Billed monthly. Pause or cancel from your dashboard in one click. Final price is set after clinician review and may vary based on dose.

Included
  • Clinician review & ongoing protocol
  • Medication, syringes, alcohol pads, sharps container
  • Temperature-controlled shipping
  • Async messaging with your clinician
  • Lab certificates of analysis on your dashboard
Not included
  • Insurance coverage (this is a cash-pay membership)
  • External lab fees if your clinician orders bloodwork
Semaglutide FAQ

Treatment-specific questions.

How quickly will I see results?
Most members notice changes in appetite within the first one to two weeks and measurable weight changes by weeks four to six. Sustained results show up over several months as your titration completes — semaglutide is a longer-arc protocol, not a sprint.
How is compounded semaglutide different from brand-name versions?
The active ingredient — semaglutide — is the same molecule. Compounded preparations are formulated and dispensed by licensed 503A or 503B U.S. pharmacies under your clinician's order, and each lot is tested for potency, sterility, pH, and endotoxins. Compounded medications are not FDA-approved as finished drug products; your clinician will explain whether compounded is appropriate for you.
Do I have to inject myself?
Yes — semaglutide is a once-weekly subcutaneous injection, typically into the abdomen, thigh, or upper arm. Most members find it surprisingly painless after the first one. Detailed instructions and a video walk-through live in your member dashboard, and your clinician is one message away if anything feels off.
What happens when I stop?
Some members taper off after meeting their goal; others stay on a maintenance dose. Without ongoing GLP-1 support, appetite signals usually return over time, so your clinician plans the off-ramp deliberately — often combining a slower taper with sustainable behavioral and nutritional anchors.
Will it interact with my other medications?
Semaglutide can interact with insulin, sulfonylureas, and oral medications whose absorption depends on gastric emptying. Your clinician reviews your full medication list before prescribing and adjusts dosing or timing as needed.
Is it covered by insurance?
MyPromise is a cash-pay membership and does not bill insurance. HSA and FSA cards are accepted. The advantage is full price transparency — no claims, no surprise bills, and no formulary roulette.
Often paired with

Members who chose Semaglutide often pair it with…

Ready when you are

A promise is just a plan with a witness.

Take the twelve-minute eligibility review. A licensed clinician will read your intake, recommend a protocol — or tell you honestly that we're not the right fit. Either way, you'll know within a day.